Course of Cell Therapy: For a patient with Aseptic Necrosis of the Femoral and Humeral heads

Yuri Vorokhta, T Muratova, S O

Abstract

High-dose corticosteroids are widely used to treat acute relapses in patients suffering from multiple sclerosis. Attempts to use pulse- therapy with methylprednisolone in the treatment of a secondary progressive multiple sclerosis are known. Intravenous methylprednisolone pulse therapy (IVMP) inhibits the inflammatory cytokine cascade, dampens T cell activation, facilitates apoptosis of activated immune cells, reduces extravasation of immune cells to the CNS, and decreases expression of class II histocompatibility antigens on antigen-presenting cells.