Content variation of disubstituted adamantane in a synthetic procedure to adapalene

Lei Tian, Jian Li and Shanfa T

Abstract

Content variation of disubstituted adamatane was reported. Disubstituted adamatane was formed through an unusual Friedel-Crafts reaction of adamantanol with 4-bromoanisole. The structure of it was identified by means of an X-ray crystal structure determination