Computational systems pharmacology and docking explored diosgenin targets causal and effectors pathogenic signalling network of vascular calcification

Jeganathan Manivannan, TR Bara

Abstract

The Objective of this study is to investigate the multi-target potential of diosgenin on pathogenic network of vascular calcification due to the osteogenic transdifferentiation of vascular smooth muscle cell (VSMC). Target analysis of diosgenin was done via a ‘reverse pharmacophore mapping’ by PharmMapper server and the target network was constructed by STRING database. In this study we discovered compound-target associations, compound-pathway connections and disease-target interactions for reconstructing the biologically meaningful networks. In this study we found, diosgenin can potentially target many proteins. Among them, diosgenin targets seven important signaling and executor proteins of vascular calcification related transdifferentiation pathogenic network. This study proved that, due to the multi target potential, diosgenin may be used for vascular calcification in chronic renal failure patients in future.