Original Articles
P Shashikala and D Shruthi Kee
Abstract
Sulphonamides were the first effective chemotherapeutic agents employed systematically for the prevention and cure of bacterial infections in humans. They are called as wonder drugs of their times. Though their usage has been limited they are still being used for burns, bacterial infections in stomach. In the present work the yield of sulfathiazole was increased by using new modified method based on the available literature from which high yields with reduced time periods were successfully achieved. Sulfathiazole is prepared by Chlorosulfonation of Acetanilide to obtain an intermediate which is reacted with 2-aminothiazole. The samples of intermediate and 2-aminothiazole with ratios (3:1, 1:1, and 1:3) and with different acid acceptors named Pyridine, Sodium bi-carbonate, Di-methyl aniline and Ammonium hydroxide are studied. The analysis was done by using IR spectroscopy in FT – IR which is found to be the best method for identification of samples.