Original Articles
Parichart Hongsing1, Chanida P
Abstract
Kondagogu, Karaya and Acacia gums are natural products from the medicinal plants namely Cochlospermum gossypium L. De Candole, Sterculia urens Roxb, and Acacia senegal L. Willd. Chemical composition analysis performed by gas chromatographic technique revealed that Kondagogu gum was composed of galactose (14.64%), rhamnose (17.11%) and galacturonic acid (17.24%). Karaya gum contained rhamnose (8.91%), galacturonic acid (9.13%), galactose (14.67%) and glucuronic acid (35.59%) while rhamnose (10.63%), arabinose (21.42%), glucuronic acid (22.54) and galactose (42.57%) were found in Acacia gum. The average molecular weights by SEC analysis revealed the large structures of the studied gums (> 2,350 kDa). The viscosities of Kondagogu, Karaya and Acacia gums were investigated showing 574.08 ± 0.01, 25.02 ± 0.01 and 1.10 ± 0.01 cP respectively. Only Kondagogu gum demonstrated glucose entrapment (39.2 ± 0.2%) from diffusion through dialysis membrane. Kondagogu and Acacia gums decreased cholesterol solubility in single bile micelles (16 ± 0.04 and 23 ± 0.04% respectively). Kondagogu and Karaya gum expressed 11.6 ± 5.5% and 20.2 ± 6.4% DPPH scavenging effects. The studied gums had no inhibitory effect on α-Glucosidase. Concentration dependent reciprocal relationship on pancreatic lipase was revealed among these gums. Kondagogu showed 6% inhibitory activity on mushroom tyrosinase while Karaya and Acacia gums exhibited marginal activation on the tyrosinase enzyme.