Bis [2-(4`-aryl-1`, 2`, 4`-triazol-5`-yl)-3-methoxy-5-nitrobenzofuran] sulphides and disulphides: Synthesis and their antimicrobial potency

Sanjeevkumar Giri and K. M. Ba

Abstract

The title compounds were synthesized respectively by treating 3-methyl-5-nitro-2(4`-aryl-3`-mercapto-1`,2`,4`- triazol-5`-yl)benzofurans (1a-c) with thionyl chloride and ethanolic bromine at room temperature for 2½ hours in good yields (2a-c) (3a-c). The structural assignment of these title compounds was done on the basis of our earlier observations, analytical and spectral data. The newly synthesized compounds were subjected to antimicrobial screening using gram positive and gram negative bacteria and fungi. The results are summarized in the preceding table.