Original Articles
Derouiche Samir, Zeghib Khaoul
Abstract
The current studies evaluated whether powder A. longa and A. malaccensis (widely used in Algerian traditional medicine) has the ability to protect against lead induced haematological changes and heart oxidative stress in rats. Twenty five female rats (Wistar albino) equally divided into five groups; control and four treated groups, received either Pb, Pb + Aristolochia (Ar), Pb+ Aquilaria (Aq) and Pb+Ar+Aq. lead acetate (100mg / kg bw) is exposed for 75 days and the duration of treatment with plants (1% of diet) is 15 days. some biochemical and hematological parameters are analysed. Phytochemical screening results revealed that A. longa and A. Malaccensis aqueous extract contained various bioactive compounds, including polyphenols, saponins, terpenoids, glycosides and flavonoids. Lead acetate exposure caused a significant decrease in the red blood cell count, hemoglobin concentration, granulocytes count and heart GSH level, GST and HGOT heart activities and a significant augmentation in the heart MDA level, heart CAT and serum GOT activities in rats . Our results revealed that treatment with Aquilaria and aristolochia causes a partial correction of all of this parameters. In Conclusion, Results confirmed the beneficial effects of A. longa and A. malaccensis treatment in Pb-induced oxidative stress in heart and suggest that Aristolochia longa could therefore be considered a promising source of novel treatments for heart alteration.