Abstract
Dr. Md. Shamim Chowdhury Re
Abstract
Heart failure is a major public health issue with a current prevalence of over 23 million worldwide. Epidemiologic studies suggest that nearly one-half of patients with heart failure have a normal ejection fraction that is now termed HFpEF.LA volume has been termed “Glycosylated hemoglobin of Diastolic dysfunction”. Natriuretitic peptides are widely accepted biomarker in HFrEF patients. Now a days, it is also considered for HFpEF patients for diagnosis & prognosis purpose. Objectives: To find out the association of Left atrial Volume index (LAVI) with N-terminal Pro B-type Natriuretic Peptide level in HFpEF patients. Methods: Total 120 HFpEF patients were included after considering inclusion and exclusion criteria. Sample population were divided into two groups, Group –I: HFpEF patients with LAVI ≤34ml/m2 (n=77); Group –II: HFpEF patients with LAVI >34ml/m2 (n=43). Results: In this study mean NT-pro BNP value of group-I and group-II were 284.45(±24) pg/ml and 1673.99 (±119.90) pg. /ml respectively. Among the Demographic & clinical parameters NYHA class, Hypertension, Diabetes mellitus was statistically significant. Among the echocardiographic parameters, LV hypertrophy, Mitral inflow E/A ratio, Deceleration time, TDI derived mitral annular eʹ septal velocity, E/ eʹ (septal) ratio, were statistically significant. Statistically significant moderately positive correlation was observed between NT-proBNP level and LAVI value, correlation coefficient(r=0.553, p=0.001).Conclusion: Elevated LAVI is associated with elevated NT-proBNP level in HFpEF patients & LAVI can be used as a marker of HFpEF.