Research Article
Limce Thampi, M. Swamivel Mani
Abstract
Novel drug delivery systems like controlled release, sustained release, prolonged release etc. is one of the best method for achieving therapeutic efficacy which helps to reduce frequency of drug administration. Solid dispersions are binary or ternary component system in which a solid matrix is used as a dispersed phase.It is used as a promising approach to improve the solubility of poorly soluble drugs. To achieve a better dissolution and bioavailability of poorly water insoluble drugs, it is necessary to select the best technique for the preparation of solid dispersions .This is influenced a number of factors like stability of drugs, solvent used, molecular arrangement etc. A study was conducted using five alternatives such as solvent evaporation technique (SET),Fusion method (FUM),Spray drying technique (SDT),Lyophilisation(LYZ),and super critical fluid technology(SFT).A set of alternatives were selected based on literature review, experiments, knowledge etc. The overall ranking of all techniques helps to select the best technique for the preparation of solid dispersion as a carrier .Based on priority ranking solvent evaporation technique is the most suitable method to achieve controlled drug release from delayed release tablets.