Original Articles
Khaled S. Khalifa, Ragaa A. Ha
Abstract
The purpose of this study is to evaluate the antitumor efficiency of different concentrations of silver nanoparticles (AgNPs) biosynthesized by The blue green algae (Anabaena oryzae, Nostoc muscorum and Calothrix marchica)on Ehrlich Ascites Carcinoma (EAC) in vitro. Silver nanoparticles were synthesized by the reduction of silver nitrate in the algal aqueous extracts . The green synthesis of AgNPs through algal extracts was monitored by colour change (from bale red to brown) and UV spectroscopy range from 400-450 nm-1. Different concentrations of AgNPs were used to study their cytotoxic activity against EAC in vitro. Results of trypan blue exclusion test showed a decrease in EAC cells viability by increasing AgNPs concentration in all tested algae. The maximum inhibition percentage of EAC cells was 80% with 98μg/ml AgNPs biosynthesized by Calothrix marchi. Silver nanoparticles biosynthesized by Calothrix marchi were the most cytotoxic against EAC in vitro