Antimicrobial activity of newly synthesized hydroxamic acid of pyrimidine-5-carboxylic acid and its complexes with Cu(II), Ni(II),Co(II) and Zn(II) metal ions.

Bhawani Shankar, Rashmi Tomar,

Abstract

Four metal complexes of new hydroxamic acid, 2,4,6-trioxo-1,3-di-p-tolyl-1,2,3,4,5,6-hexahydropyrimidine-5- carboxylic acid hydroxamide (3) with Cu(II), Ni(II), Co(II) and Zn(II) metal ions have been synthesized. The hydroxamic acid and its metal complexes were characterized by simple analytical techniques such as repeated melting point (M.P.) determination, elemental analysis, running their thin layer chromatography for single spot, and spectroscopic techniques such as I.R., H1 -NMR and UV-Vis. (only for metal chelates) spectroscopy. The antimicrobial activity of the hydroxamic acid and their metal complexes were screened against two species of bacteria and two species of fungi by Serial Dilution Method. Metal complexes were found more active against both bacteria as well as fungi in the antimicrobial screening test.