Research Article
Laxmidhar Maharana, Snigdha Pa
Abstract
The hypoglycemic potential of aqueous (50, 100 mg/kg) extract of leaves of Solanum nigrum Linn (Solanaceae) was evaluated by normoglycemic rats followed by alloxan and glucose loaded hyperglycemic rats by single oral administration. The plant extract was subjected to the study of presence of different phytoconstituents by using standard qualitative chemical methods. The preliminary antioxidant potential of the extract was evaluated by spectrophotometric method, according to the Folin–Ciocalteu procedure for estimation of total phenolic content and calculated as gallic acid equivalents (GAE), whereas total flavonoid content was determined spectrophotometrically and expressed as quercetin equivalents. The related parameters like hematological, biochemical profiles including body weight variation study were also carried out in 30-days treated diabetic rats. The study report showed that the plant extract significantly (p