Antihyperglycemic and analgesic studies with methanol extract of a mixture of Cuminumcyminum and Coriandrumsativum seeds

Nurunnahar Purnima, Md. Najmul

Abstract

In oral glucose tolerance tests with methanolic extract of Cuminum cyminum and Coriandrum sativum seeds (1:1), the extract significantly and dose-dependently reduced blood glucose concentrations in glucose-loaded mice. At extract doses of 100, 200 and 400 mg/kg (i.e. 100, 200 and 400 mg each of extract from each plant seeds), the reductions in blood glucose levels were, respectively, 37.6, 44.0 and 48.7%. In comparison, a standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg, reduced blood glucose level by 51.0%. In analgesic activity tests with acetic acid induced pain model mice, the extract at the afore-mentioned three doses, significantly and dose-dependently reduced acetic acid induced abdominal constrictions in mice by 25.9, 44.4, and 59.3%, respectively, versus the 55.6% reduction obtained with a standard analgesic drug, aspirin, administered at a dose of 400 mg per kg. In both antihyperglycemic and analgesic activity studies, the effect of combined extract was greater than that obtained with extract from individual plants. The individual or combined extracts when administered to mice did not cause any acute toxicity when administered at doses up to 3000 mg per kg. Thus the seeds of the two plants may be used for controlling both high blood sugar as well as pain.