Anticoagulation and Cancer-Associated Venous Thromboembolism in Ambulatory Patients-Are Factor Xa Inhibitors the Next Logical Step?

Opinion Article

Kenneth T Moore*and Maria Lang

Abstract

Venous Thromboembolism (VTE) is the second leading cause of death in ambulatory cancer patients .Cancer patients have an approximate 4-fold greater risk of developing VTE when compared to patients without cancer. The use of chemotherapy in these patients increases VTE risk to approximately 6.5-fold. Roughly 20% of all VTE cases occurring in patients with cancer are primarily within the outpatient setting . The 1-year survival rate is approximately one-third the survival rate in cancer patients without a VTE. Because VTE complicates the course of cancer, thromboprophylaxis in this population could reduce the burden of VTE, and potentially lead to improved health outcomes.

Relevant Publications in Journal of medical oncology