Research Article
Archana Kapoor and Naiya Dhima
Abstract
Anticancer evaluation was carried out for the derivatives of benzimidazole bearing 1, 3, 4-oxadiazole nucleus (5a- 5h) by MTT assay method on human breast cancer cell line (MCF-7). Viable cells were counted after straining with Yellow MTT (3-(4,5-Dimethylthiazol-2-yl) 2,5-dimethyltetrazolium bromide) a tetrazole which is reduced to purple formazan in the mitochondria of living cells. Percentage viability of the cells was reported in co-relation to control. Compounds (5e) and (5h) had divulged good cytotoxic activity.