Original Articles
Abdulkarim M. A. Al-Kadasi and
Abstract
An efficient sonochemistry methodology is described for the synthesis of 3, 4-dihydropyrimidin- 2(1H)-ones (Biginelli reaction) by condensation of various substituted benzaldehydes, Diketone/ β-ketoester and urea/ thiourea, at ambient temperature promoted by Chlorosulphonic acid (ClSO3H) under solvent-free condition. This method gives the desired dihydropyrimidines in excellent yields in short reaction time at ambient temperature.