Research Article
Sangita S. Makone and Sandeep
Abstract
An efficient, un-catalysed and green method for the synthesis of 1,4-dihydropyridine derivatives in an aqueous media under reflux condition through a three component one pot condensation process of aldehyde, b- dicarbonylcompounds and liquid ammonia has been developed. This procedure offers several advantages including high yields, environmentally benign solvent and simple work up process