Ammonia solution catalyzed one-pot synthesis of highly functionalized pyridine derivatives

Y. I. Shaikh, A. A. Shaikh and

Abstract

A simple and efficient one-pot synthesis of highly functionalized pyridine derivatives using ammonia solution as a catalyst via three component condensations of aldehydes, malonitrile and thiols at ambient temperature just by stirring in methanol is described. It is an efficient and promising synthetic protocol to build the highly functionalized pyridine derivatives.