Value Added Abstract
Eric Bowman Jr, Laila Al-Eryan
Abstract
A Xeroderma Pigmentosum (XP) is a genetically inherited recessive disorder. XP increases risk of skin cancer: - nonmelanoma---10,000-fold, - melanomas --- 2,000-fold - tongue cancers --- 100,000-fold • Estimated XP incidences in the USA are 1 in 1,000,0001 , 1 in 20,000 in Japan 5 , and approximately 2.3/ million live births in Western Europe 5 • XP has seven different complementation groups (A-G) translated for nucleotide excision DNA repair when exposed and damaged to UV light 1 • Mutation(s) in the XP genes result in a much slower rate of DNA repair • Some XP patients become severely sunburned after minimal sun exposure with phenotypic expressions of lentigines and progressive neurological degeneration (XPA, XPD, XPG) • XPC increases the likelihood of developing, earlyonset freckles and skin cancer 1