Abstract
Jinhua Piao
Abstract
Introduction: Neoplasm of the appendix is relatively rare, with only 0.9-1.4% of all appendectomy specimens found to have it [1,2]. The GCC was first described in 1974 as a separate entity [3], and counts for less than 5% of all primary appendix neoplasms, with an average age of 58.8 [4]. Adenocarcinoma ex goblet cell carcinoid is an uncommon entity characterized by both neuroendocrine differentiation and adenocarcinoma of the colon. Its histogenesis and pathogenesis still remain controversial [5-9], although it has been suggested that GCC cells are from lysozyme-producing cells in small intestinal crypts [10]. Initially, GCC was believed to be a low-grade malignancy [3], however, later studies suggested higher malignant potentials of the GCC compared to the classic appendix carcinoids [11]. In this study, we reported five new cases with symptoms of or mimicking appendicitis, and radiology imaging findings suggestive of appendicitis or an appendiceal abscess. We reviewed the literature and discussed the importance of meticulous sampling and the pitfalls of misdiagnosis due to the presence of diverticulitis in some of these patients.