A simple and rapid chromatographic technique for the quantification of Albendazole from marketed solid dosage forms

Amit Kumar De, Ashok Kumar Ber

Abstract

The current study presents a simple, rapid, accurate and precise chromatographic technique for the quantification of Albendazole from marketed formulation. A dual lambda UV-visible detector is used for the quantification purpose. The analysis is carried out on a C18 column (250mm × 4.6mm; 5μm) at a mobile phase flow rate of 0.7 ml/min. The method is found to be linear in a concentration range of 10.61μg/ml to 63.65μg/ml. The method is validated as per ICH Q2 guidelines. The mean recovery is 99.99% and was found to be precise on the basis of interday and intra-day precision studies. The limit of detection and limit of quantification is found to be 0.04 μg/ml and 1.67μg/ml respectively explaining the high sensitivity of the method. This chromatographic method is found to be suitable for the regular analysis of Albendazole from bulk drug and marketed formulations.