A short synthesis of 1,5-cyclooctadiene macrocycles

M. M. V. Ramana, Shrimant V. R

Abstract

5- Cyclooctadiene derivatives were synthesized by domino intermolecular alkylation and cycloalkylation of 2 -(3,4- dihydro-1-naphthenyl ) ethanols, which were obtained from tetralones, by Reformatsky reaction followed by LAH reduction. These 8-membered macrocycles have the carbocyclic frame work of several terpenoids.

Relevant Publications in Journal of Chemical and Pharmaceutical Research