Abstract
HO Al Otaibi , MI Fatani,
Abstract
ÃÂÂÂÂÂere are two main types of vascular lesion in an infant: vascular malformations and tumors . Hemangiomas, also known as strawberry birthmarks, are the most common vascular tumors of infancy, yet surprisingly the actual incidence of infantile hemangiomas remains unknown . Some studies have reported that the incidence of hemangiomas is up to 2.6% of neonates and up to 12% of children by the first year. Hemangiomas are soі, bright, red marks over the skin and are a type of benign endothelial cell neoplasm. ÃÂÂÂÂÂe\ usually appear in the first few days to months of life . Infantile hemangiomas are oіen characterized by two subsequent phases: a growth phase in the first year of life, followed by an involution phase over the next 5-7 years or more.. ÃÂÂÂÂÂe cause is unknown but di ٴوerent factors are found to influence infantile hemangiomas, such as family history, gender, race, preterm status, and low birth weight, as well as whether an infant is the product of multiple gestations or born to older mothers. ÃÂÂÂÂÂese factors have been explored in many studies and may provide clues to their pathogenesis. ÃÂÂÂÂÂe role of genetics in IH is only partially understood. Most IHs occurs sporadically. Familial clustering has been reported, even though genetic predisposition is controversial. Evidence exists that some IHs are inherited. Walter et al reported 6 pedigrees with an autosomal dominant inheritance of high penetrance; for 3, linkage to chromosome 5q31-33 was proposed. In a small number of patients, genetic variants were associated with germ line mutations in the VEGFR2, VEGFR3 and TEM8 genes; these genes regulate major angiogenesis-signaling pathways, suggesting hyper activation of VEGFR2 signaling in the pathogenesis of IH. Infantile hemangiomas are oіen benign with a self-limited course. However, in some cases they may cause complications such as permanent disfigurement and ulceration, which can lead to pain, bleeding, scarring, and infection. ÃÂÂÂÂÂe diagnosis of infantile hemangiomas is usually based on the clinical appearance of the lesions. He study included patients who were diagnosed with infantile hemangiomas from a logbook in the Dermatology Department of Hera General Hospital. ÃÂÂÂÂÂe datasheet included demographic, prenatal, perinatal and clinical data, along with information about complications and treatment modalities. Statistical analysis was carried out using SPSS 13.0. ÃÂÂÂÂÂe data were evaluated using descriptive statistical methods (mean ± standard deviation, median, frequencies and percentages). For all continuous factors, a univariable analysis was performed using chi-squared tests. A two-tailed P value less than 0.05 was considered statistically significant. Results ÃÂÂÂÂÂe medical records of 61 patients were examined. Most of our patients were female (69.9%), and the female-to-male ratio was 2:1. ÃÂÂÂÂÂe majority of our patients (47.5%) were the product of spontaneous vaginal delivery, whilst 32.8% were delivered by cesarean section and 3.3% by ventouse delivery.. A positive family history of vascular anomalies in first-degree relatives was reported in seven patients (11.5%). ÃÂÂÂÂÂe age of the patients’ mothers ranged from 22 to 43 years, with a mean maternal age of 28.8 years (SD ± 5.8) and a median age of 28 years. ÃÂÂÂÂÂe average maternal age of first-time mothers was 26.5 years. In 58 patients (95.1%), the age of onset for lesions usually occurred before two weeks (86.2%) but also could occur at two weeks and over (13.8%). Among data available for 55 patients, the most common site of hemangioma was seen in the face (36.4%). Other locations included upper limbs (18.3%), lower limbs (12.7%), chest (12.7%), scalp (9.1%) and 3.6% for each neck, back, and buttock. A total of 88.5% of our patients presented with a solitary lesion and 11.5% with multiple lesions. Complications were noted in eight patients (13.3%), including ulceration in 9.8% of patients, infection in 1.6%, and other complications in 1.6%. Treatment was administered to 36 patients (62.1%), with five being treated with systemic steroids (8.2%), 23 with topical beta-blockers (39.7%), six with pulsed-dye laser (10.3%), and six with systemic This work is partly presented at International Conference on Aesthetic Medicine and Cosmetology, May 21-22 2018âÂâ€Â‚Singapore Vol.4 No.2 Extended Abstract Skin Diseases & Skin Care 2019 propranolol (10.3%). Hemangioma progression was seen in 57.6% of our patients. Discussion Infantile hemangiomas are the most common vascular tumors of childhood, a ٴوecting about 5% of all infants. In this small group of patients, we systematically collected demographic, prenatal, perinatal, and clinical data on infants with hemangiomas to identify significant trends of the disease, including the di ٴوerent treatment modalities. ÃÂÂÂÂÂe female to male ratio was 2:1, which is comparable with the previously published ratio that ranges from 1.4:1 to 3:1 [16-19]. ÃÂÂÂÂÂe reason for female predominance is unclear. Kindred studies have suggested that a subset of hemangiomas may be inheritable and linked to genes on chromosome 5 [20]; no genetic mutations on the X chromosome have been reported. Infantile hemangioma lesions range from a few millimeters to several centimeters in diameter. Most of our patients presented with solitary lesions (88.5%), with only 11.5% of them su ٴوering multiple lesions, which is less than the data published in one study [21]. ÃÂÂÂÂÂis may be due to a limited number of cases in our study. In one published study [22], the authors found that 51% of their patients had complications, including ulceration (13%) and infections (11%). ÃÂÂÂÂÂis is a greater amount of incidences than we found, as 9.8% and 1.6% of our patients su ٴوered ulceration and infection, respectively. ÃÂÂÂÂÂis di Ù´erence could be explained by the fact that the aim of the other research was to identify complications in hemangioma patients. We find that hemangiomas more commonly occur in premature, female infants who are the product of single gestation. More studies are needed to define further the risk factors and complications for hemangiomas and to understand the relationship between potentially confounding factors. Keywords: Infantile hemangiomas; Makkah