Research Article
Vasudeva Reddy Nagavelli, Sudh
Abstract
A facile and highly efficient method for regioselective synthesis of 1-((1-aryl-1H-1,2,3-triazol-4-yl)methyl)-1Hindole in good to excellent yields from in-situ-generated alkyne and azides by Cu(I)-catalyzed 1,3 dipolar cycloaddition (the so-called click reaction), is described. The reaction proceeds smoothly in a mixture of [BMIM][PF6] and water at room temperature without any additive. The method is a convenient means of preparation of a wide range of triazoles in a one-pot operation via a three-component reaction. The final 1, 2, 3- triazoles screened for anti bacterial activity majority of compounds shows good to excellent activity.